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Methods. The study included patients receiving either a single 300 mg loading dose of clopidogrel (n = 17) or a 75 mg dose (n = 45) for at least 7 days before sample collection.The concentrations of clopidogrel and its metabolites—the inactive H3 and the pharmacologically active H4 isomers of the thiol metabolite and the inactive carboxylic acid metabolite—in plasma samples (stabilized.
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The typical dosage of clopidogrel is 75 milligrams (mg) taken once daily. For people with acute coronary syndrome, doctors typically recommend a one-time loading dose of 300 mg on the first day of.
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Clopidogrel (Plavix) Clopidogrel (Plavix®) is an antiplatelet drug you can take to prevent blood clots. It keeps platelets in your blood from coming together and making clots. You may need clopidogrel to prevent future issues if you had a heart attack, stroke or certain types of heart surgery. Additional Common Questions.
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Clopidogrel slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot. The clot can stop blood flowing to the heart.
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Side Effects. Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that.
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Clopidogrel termasuk kategori obat yang memiliki sifat polimorfisme. Dua bentuk polimorfik Clopidogrel telah diidentifikasi dan ditetapkan sebagai Form 1 dan Form 2. Form 1 dan Form 2 memiliki indikasi yang sama. Perbedaan antara dua bentuk kristal terletak pada susunan kation Clopidogrel dan anion sulfat.
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Oral: 75 mg once daily in combination with aspirin; duration of clopidogrel depends on degree of stenosis. Stenosis of 50% to 69%: Clopidogrel may be added to aspirin for 21 days; after 21 days, discontinue clopidogrel and continue aspirin indefinitely (Ehtisham 2019).
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Clopidogrel oral tablet is a prescription drug that's available as the brand-name drug Plavix.It's also available as a generic drug. Generic drugs usually cost less than the brand-name version.
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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.
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Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).. Clopidogrel is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
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Clopidogrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take clopidogrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clopidogrel exactly as directed.
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Absorption. A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. 9 Clopidogrel can be taken with or without food. 9 A meal decreases the AUC of the active metabolite by 57%. 9 The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. 9 Clopidogrel reached a C max of 2.04±2.0ng/mL in 1.40±1.07h. 5 The AUC for a 300mg oral dose of clopidogrel was.
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Clopidogrel is an inactive prodrug that requires enzymatic activation via a variety of CYP enzymes, including the CYP2C19 and CYP3A4 enzymes, through a two-step process of bioactivation. Genetic polymorphisms to these enzymes can influence response to therapy.
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Clopidogrel merupakan pengencer darah, yang bekerja dengan menghambat pelekatan trombosit dan penyumbatan berbahaya. Clopidogrel digunakan untuk mengurangi kejadian trombolitik pada infark miokard yang belum lama terjadi, stroke, atau penyakit arteri perifer, sindrom koroner akut.
