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In addition, rebamipide treatment is more cost-effective and results in a better quality of ulcer healing compared with the PPI lansoprazole. Go to: INTRODUCTION Endoscopic mucosal resection (EMR) is a well-established curative treatment for gastric neoplasms, such as early gastric cancer confined to the mucosa.
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Abstract OBJECTIVES: To evaluate the healing efficacy of rebamipide and lansoprazole combination therapy with lansoprazole alone for endoscopic submucosal dissection (ESD)-induced ulcers and clarify the ulcer healing-associated factors. METHODS: Three hundred patients were randomized into control and experimental groups after they underwent ESD.
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Rebamipide, a drug that stimulates the synthesis of prostaglandin and mucous glycoprotein, inhibits active oxygen, inflammatory cytokines and chemokines, and suppresses the activity of leukocytes, is recognized as a representative defensive medication against inflammatory processes. 5 In addition, a portion of reflux esophagitis patients have ga.
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Therefore, our research goal was to compare the effectiveness of rebamipide and lansoprazole through a multi-center, randomized, open labeled, pilot study. In this work, cyclooxygenase-1 (COX-1) inhibition was compared between lansoprazole and rebamipide with meloxicam; and the effect on NSAID-induced gastro-enteropathy in patients requiring.
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The rebamipide and lansoprazole combination therapy can help accelerate the reduction rate of post-ESD ulcer compared with the lansoprazole monotherapy at 4 weeks of therapy. Go to: INTRODUCTION
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Combination of proton pump inhibitor and rebamipide, a free radical scavenger, promotes artificial ulcer healing after endoscopic submucosal dissection with dissection size >40 mm - PMC Journal List J Clin Biochem Nutr v.51 (3); 2012 Nov PMC3491242 As a library, NLM provides access to scientific literature.
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Aims: To investigate the effects of rebamipide on the Helicobacter pylori eradication rate with amoxicillin and omeprazole. The trial also examined its histological effects on gastro-mucosal inflammation after eradication. Methods: Two hundred and six H. pylori-positive patients with active gastric ulcer underwent 8-week based therapy (OA) consisting of 2-week amoxicillin with omeprazole and.
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Although statistically significant differences were not generated, possibly as a result of the small sample size, mucosal breaks observed via capsule endoscopy revealed that rebamipide was likely to be more effective than lansoprazole in preventing small intestine damage caused by NSAIDs. Furthermore, fewer side-effects emerged with rebamipide.
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The anti-inflammatory function of rebamipide may be effective for protecting the esophageal mucosa. This prospective randomized multicenter placebo-controlled study was performed to clarify the efficacy of rebamipide for NERD patients whose reflux symptoms were refractory to PPI treatment.
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Conclusion: Although statistically significant differences were not generated, possibly as a result of the small sample size, mucosal breaks observed via capsule endoscopy revealed that rebamipide was likely to be more effective than lansoprazole in preventing small intestine damage caused by NSAIDs.
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Objective. To contrast the effect of rebamipide with proton pump inhibitors (PPIs) versus PPIs alone for the treatment of endoscopic submucosal dissection (ESD-) induced ulcers. Methods. PubMed, Embase, the Cochrane library, the WanFang database, and China National Knowledge Infrastructure (CNKI) were searched to identify studies that met the inclusion criteria. Results. Nine randomized.
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previously demonstrated that addition of rebamipide to 15 mg of lansoprazole more effectively controlled the recurrence of symptoms than 15 mg of lansoprazole monotherapy in patients with reflux esophagitis whose symptoms were relieved by administration of full-dose PPI. However, the efficacy of rebamipide for the treatment of NERD has not been.
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A total of 102 H. pylori-positive gastric ulcer patients were assigned at random to two groups; in addition to dual therapy (amoxicillin 500 mg thrice daily and lansoprazole 30 mg every morning for two weeks), one group received rebamipide 100 mg thrice daily for eight weeks, while the other group received teprenone 50 mg thrice daily for eight.
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All subjects were examined by the 13 C‐UBT on four occasions: (i) without medication (control); (ii) after the administration of 30 mg lansoprazole (u.i.d) for 14 days; (iii) after the administration of 100 mg rebamipide (t.i.d) for 14 days; and (iv) after the administration of 20 mg famotidine or 75 mg roxatidine (b.i.d) for 14 days. In the.
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The fundamental questions that need to be examined may be summarized as follows: Can rebamipide: (i) prevent H. pylori infection; (ii) reduce inflammation in infected subjects; (iii) accelerate healing after eradication therapy; (iv) promote ulcer healing; (v) prevent progression of pre-neoplastic lesions?
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Rebamipide is known to increase the mucosal generation of prostaglandins and to eliminate free oxygen radicals, thus enhancing the protective function of the gastric mucosa. However, it is unknown whether rebamipide plays a role in preventing NSAID-induced gastropathy.
