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Background [Superparamagnetic iron oxide nanoparticles (SPION) stabilized by alginate (SPION-alginate) have been developed as a contrast agent to improve the sensitivity of magnetic resonance imaging (MRI) in the detection of hepatocellular carcinoma (HCC) ().MRI is an imaging modality that is used to construct images of the nuclear magnetic resonance (NMR) signal, primarily from the hydrogen.
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Superparamagnetic iron oxide nanoparticles (SPION) have a great potential in both diagnostic and therapeutic applications as they provide contrast in magnetic resonance imaging techniques and allow magnetic hyperthermia and drug delivery. Though various types of SPION are commercially available, efforts to improve the quality of SPION are highly in demand. Here, we describe a strategy for.
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SPION-induced production of ROS through the Fenton/Haber-Weiss reaction hence appears as a prominent asset to guide future directions in the field of SPION-based therapies. Numerous theranostic SPION-based platforms have been designed and have shown promising results, alone or in combination with other therapeutic strategies (RT, chemotherapy
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Various efforts are directed towards improving these SPION properties and modifying their synthesis methods to better control their size and surface. A number of recently published reviews address these approaches collectively or separately as well as focus on specific applications of SPIONs [22], [26], [27], [28]. In this comprehensive review.
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SPION are divided into three main categories based on their hydrodynamic diameter: oral SPION, 300 nm-3.5 ยตm; standard SPION (SSPIO), 50-150 nm; and ultrasmall SPION (USPIO), <50 nm ().SPION that are 10-100 nm in size are considered to be optimal for intravenous administration whereas particles >200 nm and <10 nm are sequestered by the spleen or removed through renal clearance.
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Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation.
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3.2.4 Magnetic nanoparticles. Superparamagnetic iron oxide nanoparticles (SPIONs) have been studied for various biomedical applications, such as contrast agents, iron replacement therapies, drug delivery, tissue repair, hyperthermia, cell and tissue targeting, and transfection. SPIONs have an iron oxide core that is coated by an organic or.